Low-molecular-weight heparin to prevent pre-eclampsia: there is no evidence and potential harm.
نویسنده
چکیده
منابع مشابه
Thrombophilia and Pregnancy Complications
There is a paucity of strong evidence associated with adverse pregnancy outcomes and thrombophilia in pregnancy. These problems include both early (recurrent miscarriage) and late placental vascular-mediated problems (fetal loss, pre-eclampsia, placental abruption and intra-uterine growth restriction). Due to poor quality case-control and cohort study designs, there is often an increase in the ...
متن کاملRecurrence rate of pre-eclampsia in women with thrombophilia influenced by low-molecular-weight heparin treatment?
OBJECTIVES (1) To assess the recurrence rate of pre-eclampsia in women with this history before 34 weeks of pregnancy and thrombophilia. (2) To evaluate the effects of low-molecular-weight heparin (LMWH) on pregnancy outcome. METHODS In a multicentre retrospective study subsequent pregnancies of women with a history of pre-eclampsia necessitating birth before 34 weeks and thrombophilia were a...
متن کاملMeta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications.
A 35-year-old woman with recurrent severe placenta-mediated pregnancy complications in her 2 pregnancies asks: Will low-molecular-weight heparin help prevent recurrent placenta-mediated pregnancy complications in my next pregnancy? We performed a meta-analysis of randomized controlled trials (RCTs) comparing low-molecular-weight heparin (LMWH) vs no LMWH for the prevention of recurrent placenta...
متن کاملThrombophilia and its impact on pregnancy.
UNLABELLED In recent years thrombophilia has gained much attention as a risk factor for pregnancy complications. Whereas there is an established correlation between antiphospholipid-antibodies and pregnancy loss, data for other risk factors of thrombosis are less well established. Data suggest associations with antithrombin deficiency, hyperhomocysteinemia and also with factor V Leiden, prothro...
متن کاملAntithrombotic therapy for pregnancy complications: let's not throw the baby out with the bath water.
Context Placenta-mediated pregnancy complications, ranging from miscarriage to growth restriction and pre-eclampsia, collectively affect more than 25% of pregnancies. While the aetiology of pregnancy complications is heterogeneous, it is plausible that common processes such as inflammation and activation of the coagulation system play key roles. Therefore, antithrombotic treatments, specificall...
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ورودعنوان ژورنال:
- The Netherlands journal of medicine
دوره 62 3 شماره
صفحات -
تاریخ انتشار 2004